Heterocyclic boronic acids display sialic acid selective binding in a hypoxic tumor relevant acidic environment† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01905j Click here for additional data file.

Heterocyclic boronic acids display sialic acid selective binding in a hypoxic tumor relevant acidic environment.

Boronic acids are well known for their ability to reversibly interact with the diol groups found in sugars and glycoproteins. However, they are generally indiscriminate in their binding. Herein we describe the discovery of a group of heterocyclic boronic acids demonstrating unusually high affinity and selectivity for sialic acids (SAs or N-acetylneuraminic acid), which are sugar residues that a...

Organocatalytic, enantioselective synthesis of benzoxaboroles via Wittig/oxa-Michael reaction Cascade of α-formyl boronic acids† †Electronic supplementary information (ESI) available. CCDC 1487136. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc04522g Click here for additional data file. Click here for additional data file.

Denitrogenative Suzuki and carbonylative Suzuki coupling reactions of benzotriazoles with boronic acids† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc00367f Click here for additional data file.

Self-assembling α,γ-cyclic peptides that generate cavities with tunable properties† †Electronic supplementary information (ESI) available: Synthetic experimental details, DFT calculation details, additional figures (relevant NMR data) and schemes (synthetic schemes for peptide and amino acid preparation). CCDC 1400134. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc03187g Click here for additional data file. Click here for additional data file.

Crystallization-induced dual emission from metal- and heavy atom-free aromatic acids and esters† †Electronic supplementary information (ESI) available. CCDC 1044990 and 1044991. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc00253b Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.